The Top 13 Biggest Companies in Boston, USA

Boston’s Billion-Dollar Brands: Who They Are, What They Do, and Why They Matter

Boston is known for its history, world-class universities, and thriving innovation scene — but it’s also home to some of the biggest, most powerful companies in the United States. From healthcare and biotech to finance, tech, and education, Boston’s corporate footprint drives billions in revenue and employs hundreds of thousands of professionals across the world.

In this article, we explore the top 13 biggest companies headquartered in Boston — ranked by revenue, influence, and global impact — including what they do, their market value, and how they’re shaping the economy in 2025.

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1. General Electric (GE)

• Industry: Industrial Conglomerate
• Headquarters: Boston, MA
• Founded: 1892
• Employees: 170,000+ (global)
• Annual Revenue (2024): $67 billion
• CEO: H. Lawrence Culp Jr.

GE moved its headquarters to Boston in 2016 to be closer to top-tier talent and the innovation ecosystem. Though it’s streamlined its focus in recent years, GE remains a global force in aviation, power, and healthcare equipment. In 2024, it completed a major restructuring into three independent companies: GE Aerospace, GE HealthCare, and GE Vernova (energy).

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2. Liberty Mutual Insurance

• Industry: Insurance & Financial Services
• Headquarters: 175 Berkeley Street, Boston, MA
• Founded: 1912
• Employees: 45,000+
• Annual Revenue (2024): $50 billion
• CEO: Timothy Sweeney

Liberty Mutual is one of the largest global property and casualty insurers. Despite the conservative branding, it’s an innovation-driven firm investing heavily in AI-powered underwriting and digital claims processing.

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3. Fidelity Investments

• Industry: Financial Services
• Headquarters: 245 Summer Street, Boston, MA
• Founded: 1946
• Employees: 70,000+
• Assets Under Management (2025): Over $11.5 trillion
• Annual Revenue Estimate: $24 billion+
• CEO: Abigail Johnson

Fidelity is one of the top asset managers in the world. With its headquarters in Boston’s Seaport District, Fidelity is leading the charge in retirement planning, mutual funds, and digital investing. The firm is privately held and still family-run — a rarity at this scale.

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4. Boston Scientific

• Industry: Medical Devices
• Headquarters: Marlborough (Greater Boston), MA
• Founded: 1979
• Employees: 45,000+
• Annual Revenue (2024): $14.5 billion
• CEO: Michael Mahoney

Boston Scientific is a global leader in life-changing medical technologies, including interventional cardiology, neuromodulation, and urology. Its products impact the lives of over 30 million patients annually.

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5. Thermo Fisher Scientific

• Industry: Biotechnology & Laboratory Equipment
• Headquarters: Waltham (Boston Metro), MA
• Founded: 2006 (merger of Thermo Electron & Fisher Scientific)
• Employees: 130,000+
• Annual Revenue (2024): $42 billion
• CEO: Marc Casper

Thermo Fisher is the silent giant behind the scenes of most pharmaceutical breakthroughs and clinical trials. It provides lab equipment, diagnostic tools, and research services to biotech firms worldwide. It also played a key role in COVID-19 testing supply chains.

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6. Wayfair

• Industry: E-Commerce / Home Goods
• Headquarters: 4 Copley Place, Boston, MA
• Founded: 2002
• Employees: 14,000+
• Annual Revenue (2024): $12 billion
• CEO: Niraj Shah

Wayfair has grown from a niche online furniture site into a publicly traded titan in home retail. Although its stock price has seen highs and lows, Wayfair remains one of the largest tech employers in Boston, with major investments in logistics and customer AI tools.

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7. Vertex Pharmaceuticals

• Industry: Biotechnology
• Headquarters: One Science Park, Boston, MA
• Founded: 1989
• Employees: 5,000+
• Annual Revenue (2024): $9.8 billion
• CEO: Reshma Kewalramani

Vertex is known for its groundbreaking cystic fibrosis treatments and a promising pipeline in rare diseases. It has one of the most admired R&D programs in biotech and is a regular on “best companies to work for” lists in the Boston area.

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8. State Street Corporation

• Industry: Financial Services / Asset Custody
• Headquarters: One Congress Street, Boston, MA
• Founded: 1792
• Employees: 39,000+
• Assets Under Custody (2025): Over $44 trillion
• Annual Revenue (2024): $12.2 billion
• CEO: Ronald P. O’Hanley

State Street isn’t a household name like Fidelity, but it quietly powers the global investment world through custodial banking, back-office solutions, and ETF infrastructure (it launched the SPDR S&P 500 ETF, SPY).

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9. DraftKings

• Industry: Sports Betting & Entertainment
• Headquarters: 222 Berkeley Street, Boston, MA
• Founded: 2012
• Employees: 4,000+
• Annual Revenue (2024): $3.6 billion
• CEO: Jason Robins

DraftKings has become one of the most well-known brands in the US for online sports betting, fantasy sports, and gaming. Now a publicly traded company, DraftKings is part of the explosive legal gambling boom in America and a flagship tech company in Boston.

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10. Mass General Brigham

• Industry: Healthcare / Hospital Network
• Headquarters: Somerville, MA (Greater Boston)
• Employees: 82,000+
• Annual Revenue Estimate: $16 billion+
• CEO: Anne Klibanski

This healthcare system includes Massachusetts General Hospital and Brigham and Women’s Hospital — both top-ranked in the U.S. The network is a leader in medical research, clinical trials, and cutting-edge treatment protocols.

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11. Iron Mountain Inc.

• Industry: Data Storage & Records Management
• Headquarters: One Federal Street, Boston, MA
• Founded: 1951
• Employees: 25,000+
• Annual Revenue (2024): $5.5 billion
• CEO: William Meaney

Iron Mountain is a leading provider of physical and digital storage, trusted by 95% of Fortune 1000 companies. From secure offsite paper records to massive data centers, it plays a crucial role in global information security.

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12. HubSpot

• Industry: Marketing Technology / CRM
• Headquarters: 25 First Street, Cambridge, MA (Greater Boston)
• Founded: 2006
• Employees: 7,400+
• Annual Revenue (2024): $2.3 billion
• CEO: Yamini Rangan

HubSpot is one of the brightest success stories in SaaS, offering an all-in-one platform for CRM, marketing automation, and customer service. It’s also beloved for its company culture and remote-first model.

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13. Toast, Inc.

• Industry: Restaurant Technology / SaaS
• Headquarters: 401 Park Drive, Boston, MA
• Founded: 2011
• Employees: 4,500+
• Annual Revenue (2024): $1.1 billion
• CEO: Chris Comparato

Toast powers POS systems and restaurant operations for thousands of restaurants across the US. From orders to payroll, it’s part of Boston’s rising SaaS scene and went public in 2021.

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Boston’s Corporate Future: Built on Innovation

Boston’s economy is uniquely diverse, spanning biotech, insurance, fintech, SaaS, and more. These 13 companies showcase why Boston is more than just a college town — it’s a global business hub. Whether you’re a marketer, startup founder, or enterprise buyer, these companies influence how we live, work, shop, and stay healthy.

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SEO Tips for Local Businesses in Boston:

• Mention Boston’s top companies in your content to capture search intent from job seekers, investors, and vendors
• Use local modifiers: “B2B marketing for Boston companies”
• Optimise for featured snippets with listicle-style content (like this one!)
• Link to local directories and embed maps when targeting local leads

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